Chronic fatigue. Persistent inflammation. Brain fog that won’t lift. For millions of people, symptoms like these linger despite testing, supplements, or even prescription treatments. That’s where EBOO ozone therapy comes in.
Short for Extracorporeal Blood Oxygenation and Ozonation, EBOO is one of the most advanced detoxification and immune-support therapies available today. It filters and ozonates your blood outside the body in real time, supporting deep cellular healing, energy production, and immune balance.
Whether you’re managing chronic illness or optimizing your performance, here’s what you need to know about this cutting-edge approach.
What Is EBOO Ozone Therapy?
EBOO is a sophisticated form of ozone therapy that treats large volumes of blood in a continuous loop outside the body. It uses two IV lines—one to withdraw blood and one to return it—connected to a closed-circuit system that infuses the blood with medical-grade ozone and oxygen while filtering out toxins and inflammatory byproducts.
Unlike conventional IV ozone therapy, which only treats a small sample of blood at a time, EBOO can process several liters during a single 45 to 60 minute session. This allows for more comprehensive therapeutic exposure and a deeper systemic effect.
The Science Behind EBOO
Medical ozone isn’t just a disinfectant. In therapeutic doses, it acts as a biological signaling molecule that can:
- Improve mitochondrial function and energy production
- Activate antioxidant pathways to neutralize oxidative stress
- Modulate the immune response—calming overactivity while enhancing pathogen defense
- Support better oxygen delivery to tissues and organs
Combined with real-time filtration, EBOO supports detoxification, reduces systemic inflammation, and restores functional balance at the cellular level.
Step-by-Step: What to Expect During EBOO Therapy
Before Your Appointment
Every EBOO protocol begins with a medical consultation. Your provider will review your health history, assess symptoms, and may order labs to evaluate markers like oxidative stress, inflammation, and detox capacity.
This helps ensure that EBOO is safe and appropriate—and that your treatment plan is personalized.
During the Treatment
A standard EBOO session lasts about 45 to 60 minutes. Here’s how it works:
- Setup: You’ll be comfortably seated or reclined in a treatment chair. IV lines are placed in both arms.
- Circulation: Blood is drawn through one IV into a closed-loop machine.
- Ozonation: As blood passes through the circuit, it is exposed to a precise mix of ozone and oxygen under sterile conditions.
- Filtration: The system uses medical-grade filters to remove toxins, heavy metals, inflammatory proteins, and cellular debris.
- Reinfusion: The treated blood is returned to your body through the second IV.
The process is typically painless. Most patients feel calm or even energized during the treatment.
After Treatment
You can resume normal activities immediately, though some people prefer to rest or hydrate for the remainder of the day. Mild fatigue or detox symptoms can occasionally occur but usually resolve within 24 to 48 hours.
Evidence-Based Benefits of EBOO Ozone Therapy
Because of its multifaceted effects—ozonation, filtration, oxygenation—EBOO is used to support a range of clinical and wellness goals.
Inflammatory Conditions
EBOO may help regulate the body’s inflammatory response, making it a supportive therapy for:
- Autoimmune diseases (rheumatoid arthritis, lupus, Hashimoto’s)
- Chronic Inflammatory Response Syndrome (CIRS)
- Post-viral inflammation, including long COVID
Detoxification Support
The filtration component actively removes:
- Environmental toxins (heavy metals, mold biotoxins)
- Inflammatory cytokines
- Metabolic waste and debris
- Compounds that burden the liver, kidneys, and lymphatic system
Neurological and Cognitive Function
Many patients report noticeable improvements in:
- Mental clarity and focus
- Mood stability
- Sleep quality
- Cognitive function in post-infectious or neuroinflammatory conditions
Chronic Infection Recovery
EBOO can help support recovery from stubborn or lingering infections, such as:
- Lyme disease and co-infections
- Epstein-Barr virus
- COVID-related complications
- Chronic fatigue syndromes
Energy, Circulation, and Performance
Because it supports mitochondrial health and oxygen delivery, EBOO is also used for:
- Athletic performance and recovery
- Hormonal balance
- General energy enhancement
- Metabolic optimization
Is EBOO Ozone Therapy Safe?
When administered by qualified providers using FDA-compliant equipment, EBOO therapy has an excellent safety profile.
Who Should Not Receive EBOO
EBOO is not recommended for patients with:
- G6PD deficiency
- Pregnancy or breastfeeding
- Active bleeding disorders
- Severe cardiovascular instability
Other conditions, like uncontrolled hyperthyroidism, recent heart attacks, or severe anemia, may require special evaluation before starting therapy.
Potential Side Effects
Most side effects are mild and temporary. These may include:
- Fatigue or lightheadedness
- Mild detox symptoms (headache, nausea)
- Tenderness at the IV site
- Emotional release or mood changes (uncommon)
Your provider will walk you through any specific risks and how to prepare for and recover from treatment.
EBOO Therapy Protocols and Timeline
Initial Series
Most treatment plans start with a series of 3 to 10 sessions based on your goals:
- Acute relief: 3 to 5 sessions over 2 to 3 weeks
- Chronic illness support: 6 to 10 sessions over 4 to 6 weeks
- Optimization: 3 to 5 sessions quarterly or seasonally
Maintenance Therapy
Some patients continue with monthly or quarterly sessions to support long-term results, prevent symptom recurrence, or maintain peak wellness.
When to Expect Results
- Immediately after treatment: Mental clarity, increased calm or energy
- Within 1 to 2 weeks: Reduced inflammation, better sleep, enhanced recovery
- Over 4 to 8 weeks: Lasting improvements in fatigue, mood, immune function, and resilience
Who Is EBOO Ozone Therapy For?
EBOO is used both therapeutically and proactively. Ideal candidates include:
Therapeutic Use Cases
- Chronic fatigue syndrome or fibromyalgia
- Autoimmune conditions
- Environmental toxin exposure (mold, chemicals, heavy metals)
- Post-viral or chronic infection syndromes
- Lyme disease or tick-borne illness
- Long COVID recovery
Performance and Prevention
- Athletes looking to boost recovery and circulation
- Executives and high-performers managing stress and burnout
- Individuals seeking anti-aging and longevity strategies
- Anyone interested in immune and detox support beyond traditional medicine
Choosing a Qualified EBOO Provider
Because EBOO is an advanced therapy, the experience and credentials of your provider matter. Look for:
- A board-certified physician with ozone therapy training
- FDA-compliant ozone and filtration equipment
- A full medical intake and safety screening process
- Transparent protocols and ongoing support
Ask questions like:
- How often do you administer EBOO?
- How do you tailor protocols to individual needs?
- What safety protocols are in place during the procedure?
- How is progress monitored over time?
How EBOO Complements Other Therapies
EBOO can be even more effective when integrated into a comprehensive wellness or recovery protocol. It pairs well with:
- Advanced lab testing: Identify nutrient gaps, inflammation markers, or toxic load
- IV therapy: NAD+, glutathione, or amino acid blends to support detox and repair
- Neuro Reset: Regulate your nervous system alongside immune and detox support
- Nutrition and lifestyle coaching: Address sleep, stress, and diet as foundational pillars
Ask your provider how EBOO can fit into a more holistic plan tailored to your goals.
Evolving Research on Ozone Therapy
While ozone therapy has been used in Europe for decades, U.S.-based research is expanding. Ongoing studies are exploring:
- EBOO’s impact on long COVID and post-viral syndromes
- Optimal protocols for autoimmune and neurodegenerative diseases
- Synergistic effects of ozone with IV nutrients and peptides
- Long-term safety and outcomes across patient populations
The field is growing rapidly, and EBOO is increasingly recognized as a promising tool in regenerative and integrative care.
Is EBOO Ozone Therapy Right for You?
If you’ve exhausted conventional options—or you’re looking to stay ahead of aging, inflammation, and chronic stress—EBOO may be the reset your body needs.
At Extension Health, we specialize in advanced diagnostics and cellular treatments designed for people who want more from their care. Our EBOO protocol is part of a personalized, medically guided approach to help you feel and function at your best.
Book a consultation today to see if EBOO therapy is right for your body, your goals, and your long-term health strategy.