core longevity blood work
Track aging biomarkers with ease.
The benefits
Identify early indicators of disease
Track key biomarkers to identify health risks, like heart disease or metabolic dysfunction, before they escalate.
Personalize your health plan
Uncover imbalances and deficiencies to personalized your diet and supplement plan for optimal health and prevention.
Take control of how you age
Use follow-up tests to monitor changes and recalibrate your lifestyle to stay ahead of age-related complications.
The blood work experience
Ten days after your blood draw, you’ll meet with our clinical team to review your results and discuss potential next steps.
Our clinical team will conduct your blood draw with precision and care, ensuring your comfort throughout the process for a smooth experience.
Common questions
How should I prepare for my blood work?
Our team will provide pre-blood draw information.
Do I need to fast?
A 4-6 hour fast is required prior to their blood draw to ensure the most accurate results
Which exact markers are included in the core longevity blood work?
Vitamin D, 25-OH (crucial vitamin for bone health, immune function, and mood regulation)
Vitamin B12 (vital for nerve function and the production of red blood cells)
Estradiol (key hormone for reproductive health)
FSH (key hormone for regulating reproductive health function)
DHEA-S (key for producing sex hormones, also linked to aging and stress)
LH (key reproductive hormone)
Dihydrotestosterone (key male reproductive hormone)
hs-CRP (key inflammation marker for assessing heart disease risk)
T4 – Thyroxine (key thyroid hormone for regulating metabolism and energy levels)
Free T3 (influences metabolism, energy use, and growth)
TSH (stimulating hormone, crucial for maintaining metabolism and energy balance)
CBC w/ differential and Platelets (a detailed count of red and white blood cells, and platelets)
Comprehensive Metabolic Panel (assesses vital organ function)
Apo B (a key protein linked to cholesterol levels)
Homocysteine (amino acid associated with cardiovascular and neurological health)
Lp(a) (cholesterol particle associated with increased risk of heart disease and stroke)
Hemoglobin A1c (long-term measure of blood sugar control)
Magnesium RBC (key for muscle function, nerve health, and metabolism)
Human IGF-1 (key for muscle repair and tissue growth)
Testosterone, Free [Total, Albumin, Sex Hormone Binding Globulin] (provides key insights into hormonal balance, muscle strength, and energy)
How often should I get follow-up blood work?
Recommended blood work frequency may depend on whether or not you have (or are at heightened risk of developing) specific chronic conditions. Generally, for those who want to proactively track their health over time, annual blood work is recommended.
How long will it take to get my results?
Your results are typically returned within 7-10 days. If you want to schedule a follow-up consultation to review your results or explore more advanced blood work options, we recommend scheduling at least 10 days after your initial blood draw.
Is blood work covered by insurance?
Blood work at Extension Health is self-pay only and not covered by insurance.
Will I experience any side effects from the blood draw?
Side effects and reactions from a blood draw tend to be mild and temporary. Some patients do report feeling dizzy or nauseous at the sight of blood. Some patients also experience light bruising and sensitivity around the area where blood is drawn.
Complete your health baseline
Build a strong foundation for your long-term health with a package that covers your cardiovascular, metabolic and musculoskeletal health, as well as your aging biomarkers.
comprehensive diagnostic package
- VO2 max
- 3D postural alignment scan
- Resting metabolic rate
- Longevity blood work
- Longevity consult
Longevity blood work
Longevity consultation
VO2 max
3D postural alignment scan
Resting metabolic rate
Not sure which treatment is right for you?
Book a consult with one of our experienced team members and they will help you get started.
References
Vitamin D
Vitamin D: The Light Side of Sunshine.
Mason RS, Sequeira VB, Gordon-Thomson C.
European Journal of Clinical Nutrition. 2011;65(9):986-93. doi:10.1038/ejcn.2011.105.
Immunologic Effects of Vitamin D on Human Health and Disease.
Charoenngam N, Holick MF.
Nutrients. 2020;12(7):E2097. doi:10.3390/nu12072097.
Infections and Autoimmunity-the Immune System and Vitamin D: A Systematic Review.
Wimalawansa SJ.
Nutrients. 2023;15(17):3842. doi:10.3390/nu15173842.
Targeted 25-Hydroxyvitamin D Concentration Measurements and Vitamin D Supplementation Can Have Important Patient and Public Health Benefits.
Grant WB, Al Anouti F, Moukayed M.
European Journal of Clinical Nutrition. 2020;74(3):366-376. doi:10.1038/s41430-020-0564-0.
Vitamin B12
A Physiological Dose of Oral Vitamin B-12 Improves Hematological, Biochemical-Metabolic Indices and Peripheral Nerve Function in B-12 Deficient Indian Adolescent Women.
Yajnik CS, Behere RV, Bhat DS, et al.
PloS One. 2019;14(10):e0223000. doi:10.1371/journal.pone.0223000.
Relationship Between Vitamin B12 and Sensory and Motor Peripheral Nerve Function in Older Adults.
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Journal of the American Geriatrics Society. 2012;60(6):1057-63. doi:10.1111/j.1532-5415.2012.03998.x.
Neuroenhancement With Vitamin B12-Underestimated Neurological Significance.
Gröber U, Kisters K, Schmidt J.
Nutrients. 2013;5(12):5031-45. doi:10.3390/nu5125031.
Laboratory Assessment of Vitamin B12 Status.
Harrington DJ.
Journal of Clinical Pathology. 2017;70(2):168-173. doi:10.1136/jclinpath-2015-203502.
Estradiol
Estrogen Levels Test.
National Library of Medicine (MedlinePlus)
Challenges to the Measurement of Estradiol: An Endocrine Society Position Statement.
Rosner W, Hankinson SE, Sluss PM, Vesper HW, Wierman ME.
The Journal of Clinical Endocrinology and Metabolism. 2013;98(4):1376-87. doi:10.1210/jc.2012-3780.
FSH
Follicle-Stimulating Hormone (FSH) Levels Test.
National Library of Medicine (MedlinePlus)
LH
Luteinizing Hormone (LH) Levels Test.
National Library of Medicine (MedlinePlus)
Dihydrotestosterone
Clinical Biochemistry of Dihydrotestosterone.
Marchetti PM, Barth JH.
Annals of Clinical Biochemistry. 2013;50(Pt 2):95-107. doi:10.1258/acb.2012.012159.
Serum Concentrations of Dihydrotestosterone Are Associated With Symptoms of Hypogonadism in Biochemically Eugonadal Men.
Sansone A, Kliesch S, Dugas M, et al.
Journal of Endocrinological Investigation. 2021;44(11):2465-2474. doi:10.1007/s40618-021-01561-0.
DHEA-S
Dehydroepiandrosterone (DHEA)–a Precursor Steroid or an Active Hormone in Human Physiology.
Traish AM, Kang HP, Saad F, Guay AT.
The Journal of Sexual Medicine. 2011;8(11):2960-82; quiz 2983. doi:10.1111/j.1743-6109.2011.02523.x
The Importance of Being Dehydroepiandrosterone Sulfate (In the Blood of Primates): A Longer and Healthier Life?.
Roberts E.
Biochemical Pharmacology. 1999;57(4):329-46. doi:10.1016/s0006-2952(98)00246-9.
Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue.
Baulieu EE, Thomas G, Legrain S, et al.
Proceedings of the National Academy of Sciences of the United States of America. 2000;97(8):4279-84. doi:10.1073/pnas.97.8.4279.
Perceived Stress at Work Is Associated With Lower Levels of DHEA-S.
Lennartsson AK, Theorell T, Rockwood AL, Kushnir MM, Jonsdottir IH.
PloS One. 2013;8(8):e72460. doi:10.1371/journal.pone.0072460.
DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.
Dutheil F, de Saint Vincent S, Pereira B, et al.
Frontiers in Psychiatry. 2021;12:688367. doi:10.3389/fpsyt.2021.688367.
hs-CRP
A Test in Context: High-Sensitivity C-Reactive Protein.
Ridker PM.
Journal of the American College of Cardiology. 2016;67(6):712-723. doi:10.1016/j.jacc.2015.11.037.
The Use of High Sensitivity C-Reactive Protein in Cardiovascular Disease Detection.
Castro AR, Silva SO, Soares SC.
Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques. 2018;21(1):496-503. doi:10.18433/jpps29872.
C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-Analyses for the U.S. Preventive Services Task Force.
Buckley DI, Fu R, Freeman M, Rogers K, Helfand M.
Annals of Internal Medicine. 2009;151(7):483-95. doi:10.7326/0003-4819-151-7-200910060-00009.
High Sensitivity C-Reactive Protein (hsCRP) and Its Implications in Cardiovascular Outcomes.
Denegri A, Boriani G.
Current Pharmaceutical Design. 2021;27(2):263-275. doi:10.2174/1381612826666200717090334.
T4-thyroxine
Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts.
Cicatiello AG, Di Girolamo D, Dentice M.
Frontiers in Endocrinology. 2018;9:474. doi:10.3389/fendo.2018.00474.
Thyroid Hormone Regulation of Metabolism.
Mullur R, Liu YY, Brent GA.
Physiological Reviews. 2014;94(2):355-82. doi:10.1152/physrev.00030.2013.
Thyroxine (T4) Test.
National Library of Medicine (MedlinePlus)
Free T3
Thyroid Function Variation in the Normal Range, Energy Expenditure, and Body Composition in L-T4-Treated Subjects.
Samuels MH, Kolobova I, Antosik M, et al.
The Journal of Clinical Endocrinology and Metabolism. 2017;102(7):2533-2542. doi:10.1210/jc.2017-00224.
Triiodothyronine (T3) Tests.
National Library of Medicine (MedlinePlus)
Circulating Free T3 Associates Longitudinally With Cardio-Metabolic Risk Factors in Euthyroid Children With Higher TSH.
Carreras-Badosa G, Puerto-Carranza E, Mas-Parés B, et al.
Frontiers in Endocrinology. 2023;14:1172720. doi:10.3389/fendo.2023.1172720.
The Role of Free Triiodothyronine in High-Density Lipoprotein Cholesterol Metabolism.
Huang F, Wu L, Qiu Y, et al.
Medicine. 2019;98(36):e17016. doi:10.1097/MD.0000000000017016.
TSH
TSH (Thyroid-stimulating hormone) Test.
National Library of Medicine (MedlinePlus)
Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement.
Jonklaas J, Bianco AC, Bauer AJ, et al.
Thyroid : Official Journal of the American Thyroid Association. 2014;24(12):1670-751. doi:10.1089/thy.2014.0028.
Thyroid Hormone Regulation of Metabolism.
Mullur R, Liu YY, Brent GA.
Physiological Reviews. 2014;94(2):355-82. doi:10.1152/physrev.00030.2013.
CBC
Interpretation of the Complete Blood Count.
Walters MC, Abelson HT.
Pediatric Clinics of North America. 1996;43(3):599-622. doi:10.1016/s0031-3955(05)70424-7.
Complete Blood Count (CBC).
National Library of Medicine (MedlinePlus)
Complete Metabolic Panel
Comprehensive Metabolic Panel (CMP).
National Library of Medicine (MedlinePlus)
Apo B
Role of Apolipoprotein B in the Clinical Management of Cardiovascular Risk in Adults: An Expert Clinical Consensus From the National Lipid Association.
Soffer DE, Marston NA, Maki KC, et al.
Journal of Clinical Lipidology. 2024;:S1933-2874(24)00240-X. doi:10.1016/j.jacl.2024.08.013.
Apolipoprotein B Compared With Low-Density Lipoprotein Cholesterol in the Atherosclerotic Cardiovascular Diseases Risk Assessment.
Galimberti F, Casula M, Olmastroni E.
Pharmacological Research. 2023;195:106873. doi:10.1016/j.phrs.2023.106873.
Physiological Bases for the Superiority of Apolipoprotein B Over Low-Density Lipoprotein Cholesterol and Non-High-Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk.
Glavinovic T, Thanassoulis G, de Graaf J, et al.
Journal of the American Heart Association. 2022;11(20):e025858. doi:10.1161/JAHA.122.025858.
Homocysteine
Homocysteine – From Disease Biomarker to Disease Prevention.
Smith AD, Refsum H.
Journal of Internal Medicine. 2021;290(4):826-854. doi:10.1111/joim.13279.
The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice.
Moretti R, Caruso P.
International Journal of Molecular Sciences. 2019;20(1):E231. doi:10.3390/ijms20010231.
Homocysteine and Homocysteine-Related Compounds: An Overview of the Roles in the Pathology of the Cardiovascular and Nervous Systems.
Djuric D, Jakovljevic V, Zivkovic V, Srejovic I.
Canadian Journal of Physiology and Pharmacology. 2018;96(10):991-1003. doi:10.1139/cjpp-2018-0112.
Homocysteine Test.
National Library of Medicine (MedlinePlus)
Lp(a)
Lipoprotein (A): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.
Shah NP, Pajidipati NJ, McGarrah RW, et al.
The American Journal of Cardiology. 2020;126:94-102. doi:10.1016/j.amjcard.2020.03.043.
All We Need to Know About Lipoprotein(A).
Bess C, Mehta A, Joshi PH.
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Considerations for Routinely Testing for High Lipoprotein(A).
Nurmohamed NS, Moriarty PM, Stroes ES.
Current Opinion in Lipidology. 2023;34(4):174-179. doi:10.1097/MOL.0000000000000838.
New Horizons: Revival of Lipoprotein (A) as a Risk Factor for Cardiovascular Disease.
Nestel P, Loh WJ, Ward NC, Watts GF.
The Journal of Clinical Endocrinology and Metabolism. 2022;107(11):e4281-e4294. doi:10.1210/clinem/dgac541.
Lipoprotein(a) and Cardiovascular Disease.
Kamstrup PR.
Clinical Chemistry. 2021;67(1):154-166. doi:10.1093/clinchem/hvaa247.
Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment.
Lampsas S, Xenou M, Oikonomou E, et al.
Molecules (Basel, Switzerland). 2023;28(3):969. doi:10.3390/molecules28030969.
Lipoprotein(a) and Cardiovascular Disease.
Nordestgaard BG, Langsted A.
Lancet (London, England). 2024;404(10459):1255-1264. doi:10.1016/S0140-6736(24)01308-4.
Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association.
Reyes-Soffer G, Ginsberg HN, Berglund L, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2022;42(1):e48-e60. doi:10.1161/ATV.0000000000000147.
Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic Analysis.
Björnson E, Adiels M, Taskinen MR, et al.
Journal of the American College of Cardiology. 2024;83(3):385-395. doi:10.1016/j.jacc.2023.10.039.
Hemoglobin A1C
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus.
Sacks DB, Arnold M, Bakris GL, et al.
Diabetes Care. 2023;46(10):e151-e199. doi:10.2337/dci23-0036.
Hemoglobin A1c-Using Epidemiology to Guide Medical Practice: Kelly West Award Lecture 2020.
Selvin E.
Diabetes Care. 2021;:dci210035. doi:10.2337/dci21-0035.
Magnesium RBC
Magnesium in Prevention and Therapy.
Gröber U, Schmidt J, Kisters K.
Nutrients. 2015;7(9):8199-226. doi:10.3390/nu7095388.
Magnesium Biology.
Kröse JL, de Baaij JHF.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association – European Renal Association. 2024;:gfae134. doi:10.1093/ndt/gfae134.
An 8-Year Analysis of Magnesium Status in Elite International Track & Field Athletes.
Pollock N, Chakraverty R, Taylor I, Killer SC.
Journal of the American College of Nutrition. 2020;39(5):443-449. doi:10.1080/07315724.2019.1691953.
Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by P Magnetic Resonance Spectroscopy, Than With Serum Magnesium.
Cameron D, Welch AA, Adelnia F, et al.
Frontiers in Physiology. 2019;10:1454. doi:10.3389/fphys.2019.01454.
Human IGF-1
The Therapeutic Potential of IGF-I in Skeletal Muscle Repair.
Song YH, Song JL, Delafontaine P, Godard MP.
Trends in Endocrinology and Metabolism: TEM. 2013;24(6):310-9. doi:10.1016/j.tem.2013.03.004.
Mature IGF-I Excels in Promoting Functional Muscle Recovery From Disuse Atrophy Compared With Pro-Igf-Ia.
Park S, Brisson BK, Liu M, Spinazzola JM, Barton ER.
Journal of Applied Physiology (Bethesda, Md. : 1985). 2014;116(7):797-806. doi:10.1152/japplphysiol.00955.2013.
Insulin-Like Growth Factor I as a Biomarker of Health, Fitness, and Training Status.
Nindl BC, Pierce JR.
Medicine and Science in Sports and Exercise. 2010;42(1):39-49. doi:10.1249/MSS.0b013e3181b07c4d.
Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle.
Vassilakos G, Barton ER.
Comprehensive Physiology. 2018;9(1):413-438. doi:10.1002/cphy.c180010.
Genetically Predicted Insulin-Like Growth Factor-I in Relation to Muscle Mass and Strength.
Yuan S, Larsson SC.
Clinical Endocrinology. 2021;95(5):800-805. doi:10.1111/cen.14561.
Testosterone, Free [Total, Albumin, Sex Hormone Binding Globulin]
Role of Sex Hormone-Binding Globulin in the Free Hormone Hypothesis and the Relevance of Free Testosterone in Androgen Physiology.
Narinx N, David K, Walravens J, et al.
Cellular and Molecular Life Sciences : CMLS. 2022;79(11):543. doi:10.1007/s00018-022-04562-1.
The Role of Testosterone in the Elderly: What Do We Know?.
Barone B, Napolitano L, Abate M, et al.
International Journal of Molecular Sciences. 2022;23(7):3535. doi:10.3390/ijms23073535.
Testosterone Levels Test.
National Library of Medicine (MedlinePlus)
Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes-2024.
Diabetes Care. 2024;47(Suppl 1):S52-S76. doi:10.2337/dc24-S004.
